Pierce has garnered widespread acclaim for his ability to portray a diverse range of characters with depth and authenticity. He has appeared in numerous notable roles, including Detective Bunk Moreland in the HBO series The Wire, trombonist Antoine Batiste in the HBO series Treme, and Robert Zane on Suits.
Additionally, Pierce has showcased his talent on Broadway, earning Tony Award nominations for his performances.
Off-screen, he is also known for his philanthropic efforts and advocacy for causes such as education and revitalizing his hometown of New Orleans after Hurricane Katrina.