In a new movie, that is.

The Grey's Anatomy star is set to appear in Knocked Up, a Universal Pictures project and writer/director Judd Apatow's follow-up to his successful The 40-Year-Old Virgin. The film is scheduled for a 2007 release, and revolves around an unexpected pregnancy and other consequences of a one-night stand. Why anyone would leave Katherine after a one-night stand is perplexing, but that's just us.

Heigl, who stars as Dr. Isobel "Izzie" Stevens on Grey's Anatomy, takes over the role vacated by Anne Hathaway, star of The Princess Diaries and Brokeback Mountain. Hathaway withdrew from Knocked Up due to creative differences. Seth Rogan, Paul Rudd and Leslie Mann, all of whom starred in The 40-Year-Old Virgin, have been cast along with the 27-year old Heigl.

Katherine's most recent film was The Ringer, where she starred alongside Johnny Knoxville, as he tried to fix the Special Olympics. What a jackass!

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.