Every Thursday, Patrick Dempsey, 40, sends hearts aflutter as Dr. Derek Shepherd on Grey's Anatomy. Playing the role of a romantically conflicted and enormously talented brain surgeon, the actor resuscitated his career and made "McDreamy" part of the pop culture lexicon.

"Patrick has always been an incredibly down-to-earth, kind person," Debra Messing, his one-time Will & Grace co-star, tells Us Magazine, which has Dempsey on its cover this week. "He's been around for a long time and has his head on his shoulders. I could not be more thrilled for him." 

Dempsey’s personal life is also booming. He and his wife of seven years, celebrity makeup artist and hairstylist Jillian Dempsey, 40, are expecting twin boys. The newborns will join the couple's daughter, Tallulah, who is four.

"I’m really thrilled," Patrick told Ryan Seacrest on the American Idol host's radio show last week. "My wife looks great, we're excited, my daughter’s happy and we’re going to have a very big family very soon."

Indeed, his marriage is the stuff McDreamy can only, well, dream of.

"I value my relationship even more now. It’s made me successful, and I am very fortunate that I don't lose sight of that," he said.

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.