We all know Patrick Dempsey is the sexiest man alive. In the eyes of millions of Grey's Anatomy fans, it's no contest.

But apparently another handsome gentleman - one who used to play a hot doctor on TV - has edged Patrick out for People Magazine's annual honor.

Yes, former ER star George Clooney was named Sexiest Man Alive by People for the second time. But Patrick still made the magazine's cover (right), and is featured inside along with various other hunks. We'll take it. Being an also-ran isn't shabby when you're going up against the likes of Clooney and Brad Pitt.

Patrick, 40, is married to stylist and cosmetics executive Jillian Fink Dempsey. They have a (very cute) 4-year-old daughter, Tallulah, and Jillian is currently pregnant again -- with twins!

The former teen heart throb is enjoying his second go-around with fame and has a sense of humor about his sudden burst of sexiness.

"This is so funny. I'm a hunky guy now," he says. "How did that happen?"

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.