Rob Lowe: Almost Dr. McDreamy

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We knew that Isaiah Washington originally tried out for the role of Dr. Derek Shepherd during the casting of Grey's Anatomy before being offered the role of Dr. Preston Burke. But it turns out he's not the only well-known (and handsome) actor to have been considered for the McDreamy role that went to Patrick Dempsey and revitalized his career.

Former "Brat Pack" member and West Wing star Rob Lowe is said to have been in serious talks about playing Dr. Shepherd - and the actor himself withdrew from consideration. In a recent interview, he said it was the first time in his career that he chose wrong.

Crazy stuff. The only wrong choice Patrick made (in his own words) was Addison over Meredith in Season 2, but that isn't really the same.

Rob Lowe as Sam Seaborn
Patrick Dempsey as Dr. Derek Shepherd

There could never be another Derek, which Dempsey portrays to perfection and displays wonderful chemistry with Ellen Pompeo. But you have to admit that Rob Lowe has certain McDreamy qualities. He recently joined the cast of ABC's Brothers & Sisters, however, so you can catch him there!

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.

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Grey's Anatomy Quotes

Meredith: You're me.
Amelia: What?
Meredith: You're me before Derek. I can be here for you. I can do this. I get you. I can be a twisted sister for you. Just tell me how do you want to play this?

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)