ABC's Grey's Anatomy makes it's way back September 27 with a bunch of changes. The season premiere is titled "A Change is Gonna Come," in fact.

Indeed, Kate Walsh is off to an ABC spin-off called Private Practice and gone is Isaiah Washington to Bionic Woman (and eventually his own series) with NBC.

So what's up with Grey's Anatomy? Us Weekly reports that executive producer Krista Vernoff says expect loads of drama. For one, she dishes on an intern that will be under Meredith Grey's tutelage this season.

Follow the jump for a picture of Mer's new intern ...

That's right, it's none other than George O'Malley!

George (T.R. Knight), dealing with a bizarre love triangle and the fallout from failing his intern exam, is going to be under the guidance of none other than his former crush (and one-night lover), Meredith.

"He's going to be Meredith's intern!" Krista Vernoff admits.

Also off to a rough start in Season Four is Cristina Yang (Sandra Oh), who comes back from her honeymoon - she brought Meredith (Ellen Pompeo) with her - to find that ex-fiancée Dr. Burke is nowhere to be found.

Lastly, according to Sara Ramirez (Callie), "I don't want to tease about anybody else's character, because I don't want anyone getting mad at me, but my character, Callie Torres, is finally going to admit to herself what's going on with the relationship with George, and she's going to do something about it."

Interesting stuff! What do you think?

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.