Episode Guide, Quotes, Photos, Music & More!

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It was a long, long wait, but the premiere of Season Four of Grey's Anatomy did not disappoint. Change most certainly did come to Seattle Grace last night, in just about every possible way. Relive the action or see what you missed in our episode guide! From our main episode page you can access everything you need to know!

We've also put together a guide to the episode's music (with lyrics, and NEW notes telling you when each track was played), as well as a photo gallery, and we are in the process of working on our list of memorable quotes. As always, feel free to comment and discuss this exciting episode with fellow fans in our forum!

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Damn! All those pithy comments were supposed to end with "used and abused." Please ignore the rest! Mia culpa.


I'm a big fan of Grey's Anatomy but I don't share most reviewers' glowing praise for Season 4.
Episode One was a far cry from "shiny happy people holding hands" and the relative levity only seemed so in contrast to a heavy Season 3. If any GA writers are reading this, I have a comment to make that hopefully won't sound preachy: My husband I both find GA has become increasingly and disturbingly devoid of morals, to the point that it's like watching a train wreck without any emotional investment in who survives. The George/Izzie/Callie triangle is sickening. What message are you sending to viewers when an innocent woman is the constant target of abuse from other women, apparently because she isn't a blonde supermodel? I am way past tired of seeing Callie get the Mean Girls treatment. It's time for her to stand up for herself and knock Izzie off her high, adulteress horse. I'd love to see Callie leave George for someone who actually has a backbone. And seriously, how anyone can champion Izzie's romance is beyond me. One minute she's grieving over the supposed love of her life, the next minute she's got her knickers in a knot because her best friend is married and apparently GA writers expect us to cheer Izzie on as she
brazenly tries her best to destroy a marriage without so much as a hint of a guilty conscience. I guess I'm the old-fashioned type who'd still like to believe that marital vows mean something. And that having a darker complexion doesn't mean it's ok to get used and abused. I'd love to see Callie wipe the smile off Izzie's face.
I can't understand why And what message does it send about marriage when vows are reduced to a joke, and where


OK, sorry to be rude, Izzie, but you are full of it. I fell in love with my best friend and though we had the very deeep friendship connection like Gizzie had, it took us 5 years to fall in llove. My best friend amrried her guy best friend and it took them 4 years to fall in love. I could go on and on about it. It happens all the time, not everyone has love at first sight. And before you forget, those three seasons were just one year and I have thought Izzie had feelings for George since Callie first got into the picture in season 2, so falling in love with someone after a few months makes perfect sense. I wonder if some of the Gizzie haters have ever had a relationship or know anything about life with the things they say. I have to say that best friends do make the best lovers and Gizzie proves that. They are amazing!


Why is Cristina numbering her interns not in quotes section? :(


I hate George and Izzie - that's sooo much grap! Sometimes I ask myself if Shonda Rhimes actually has a life of her own to write such bullshit! Sorry, first of all: you don't fall into love with all your roomates. And second: when you are such good friends like Izzie and George than EITHER u feel such a connection pretty much at the beginning or NEVER... but not like that...it is just not working.. only in such stupid shows like Melrose Place!
So... everybody who loves this grap is so far from real life situations... as nobody - except of Britney Spears who has NO Brain.. marries and realizes two days later that he is actually in love with another person... except you marry to stay in a country!


I thought last night was great! GA is definately back! There were so many things in last nights episode that I really liked and one of my favorites was Mer/Der at the end. They won't actually break up.....they love each other and I am SO GLAD that Derek finally gets Meredith! I loved it when he told Mark off...letting him know what Meredith had gone through! At least now we know Mer/Der are on the same page. I think Der will wait for Meredith.....until she gets her act together!


Love the george and izzzie combo, but they need to steam it up a little, draw out them really getting together a little longer.........Don't like the character of Meredith's sister (BOOORING). Derek and Meredith stay together, but, there has to be some "conflict"/"yearning" because People will get bored with happily ever after for too long...............
I'm tired of the poor put upon Callie. Nobody likes her, BOO HOO. I like her character, but am over her pity party. Glad McSteamy stayed on, but, hope they give his character a little more depth, and make him slightly more likeable/vulnerable.


I agree, I was pleased with the episode. It was was not over the top like they were trying too hard, it was great. I am a big fan of George and Izzie, I can understand why some are not, but I can't wait to see how things work out for them. I love TR, he is such and amazing actor. The Mer/Der "break up sex" was awesome but I don't want to see them just be f**k buddies, they both deserve better than that. Can't wait till next week! Thank God for TiVo I am gonna watch it again tonight ;)


I loved this episode. Izzie saving a deer...that is so like her. Lexie was nice and she did sound just like Meredith. I agree...what was with Alex's hair. I loved the Sloan part, wanting Derek back...that was hilarious. I especially loved the ending...i think George & Izzie will make a great couple. BTW, My audio was fine.


I totally agree with you Firefly! I loved the entire episode... I just hope they don't focus too much on the interns! I just want to know about our GA crew! I love the last scene with MerDer... Much needed!

Grey's Anatomy Quotes

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)

Derek: I am calling post-it, Zola, Bailey, the tumors on the wall, ferryboat scrub caps. I thought D.C. was everything. I was wrong. You... you're everything. I love you and I'm not going to stop loving you. I can't live without you. I don't want to live without you, and I'm going to do everything in my power to prove it.
Meredith: I can live without you, but I don't want to. I don't ever want to.