Episode Guide, Quotes, Photos, Music & More!

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It was a long, long wait, but the premiere of Season Four of Grey's Anatomy did not disappoint. Change most certainly did come to Seattle Grace last night, in just about every possible way. Relive the action or see what you missed in our episode guide! From our main episode page you can access everything you need to know!

We've also put together a guide to the episode's music (with lyrics, and NEW notes telling you when each track was played), as well as a photo gallery, and we are in the process of working on our list of memorable quotes. As always, feel free to comment and discuss this exciting episode with fellow fans in our forum!

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I loved it except the AUDIO. Why are they whispering and mumbling so much? Or was it my feed. I couldn't tell if Meredith and Derek were breaking up, or what they said. I also couldnt hear what Derek told Christina about Burke after he said "turned in his resignation....". anyone else?


I would be so happy if Izzie was pregnant, a little George and Izzie baby would be so cute.


notice how Izzie made a point to say 17 days ...maybe they are throwing time in there so you get a feell that not a lot of time has passed since the end of season 3 .... so maybe Izzie's the one thats pregnant and not Callie like they'd lead you to believe .... hmmmm, thoughts anyone????


I loved the whole episode, especially the George and Izzie thing. They are so wonderful together! I started jumping up and down, go Gizzie! The MerDer thing was a bit depressing though.


I was beyond pleased with this episode. Especially at the end with George telling Izzie that he loves her. I was a bit sad with McDreamy and Mer breaking up, but I think they'll get back together at some point. If they're really meant to be. I'm glad Mark's staying, I always found him funny. But Alex needs a shave... Lexie is freaking cool. The part with Izzie shocking that deer was hilarious.
Excellent work, Shonda!!


Oh My God !!
I'm sooo happy about the opener,- It was crazy, funny, sad,.. going back to it's roots I'd say,.. I loved them as residents and having a taste of "Being Bailey",.. loved them dissing Callie, even the George/ Izzie scenes weren't annoying ! (so happy about that btw).
So many great scenes,- Izzie telling off her interns,- yay Izz !! Mark wanting Derek back,- LMAO !! Christina finally realizing what Burke REALLY meant to her,... poor girl,...
But my favorite part was Dereks defensiveness of Mer to Mark. I'm glad they wrote in that he finally "gets" her,.... and enough to let her fake break up with him to edge in a little closer, cuz we all know that having things up in the air is Mer's comfort zone.
Great start Grey's writers !!


seriously I do. It was SO AWESOME.
Meridith and Derek: HOT HOT SEX... as always
George and Izzie: I love the idea of the two of them together, BUT POOR CALLIE. The girl doesnt need to have her heart broken
Lexie: Was fiesty and ALOT like her sister. I like her, and George does. I think Christina and Derek will like her too inspite of themselves. Meridith wont give her a chance because Meridith cant even stand herself
Ales: The star of the episode! He' s STALKING Ava. But he did such a good job! I loved how he jumped on it to save that guy. BUT THE BEST PART OF THE EPISODE was when he conforted Christina in a way that only Alex Karev can. He took care of her without making it so obvious that she would refuse his help. He's grown so much
Christina: Will be all right. Her fiasco with Burke has clearly made her a better doctor (the way she talked to the patient was fantastic).
Baily and Chief: Baily loves her five interns, and its hard to watch them suffer under Callies rule. However, the cheif is right. He wants Baily to focus on her craft. Baily needs to learn what the attending already know; the cheif knows what he's doing when he makes PROFESSIONAL assignments... now... if he could get his PERSONAL life together
Mark: Really does care about Derek, and inspite of bad history, both of them WILL learn and grow.


The Season Premier Was GREAT!!!
I was very pleased. It felt good- a long time coming...


It was weird seeing them as residents! I predict that Lexie and George are going to become best friends, Callie is going to be pregnant and will step down as chief and miranda will take over. What the hell was with Alex's hair? He looked really weird. And what the hell is Mark Sloan still doing there? Meredith and Derek better stay together cause I can't take it. haha Lexie talks just like Meredith, its creepy. And I loved how Meredith just snubbed here..and I also loved when they all yelled at the new interns for trying to hang out in their place..Izzie was the funniest. Overall, it was a good episode but its gonna take some getting used to!!


Grey's Anatomy Quotes

When we say things like "people don't change" it drives scientist crazy because change is literally the only constant in all of science. Energy. Matter. It's always changing, morphing, merging, growing, dying. It's the way people try not to change that's unnatural. The way we cling to what things were instead of letting things be what they are. The way we cling to old memories instead of forming new ones. The way we insist on believing despite every scientific indication that anything in this lifetime is permanent. Change is constant. How we experience change that's up to us. It can feel like death or it can feel like a second chance at life. If we open our fingers, loosen our grips, go with it, it can feel like pure adrenaline. Like at any moment we can have another chance at life. Like at any moment, we can be born all over again.


Callie: Did anyone ever think you two were a couple?
Meredith: No, because we screw boys like whores on tequila.
Cristina: Then we either try to marry them or drown ourselves.
Callie: Huh.