E! Online has uncovered some solid Grey's Anatomy spoilers after sitting down for a one-on-one talk with the always intriguing Eric Dane, who hinted at a big romance coming up for his character, Mark Sloan, in the upcoming season five.

Some of these Grey's Anatomy spoilers are actually kind of juicy. If you wish to learn some of the details Dane shared, as well as what's up in the love lives of Drs. Izzie Stevens and Meredith Grey, you'll have to follow the jump ...

Is McSteamy finding the McOne?

The always steamy Eric Dane hinted that Dr. Mark Sloan might finally meet his romantic match this year, telling E!'s Kristin Dos Santos:

"I think he's going to [find real love] this season. I don't know how long that's going to last. The nature of the show is people don't stay together very long. We always end up back together, and then we break up again, then we get back together again — but I think this year he's going to find somebody."

Now, the money question: Is it someone we know?

"I hope so," Eric said with his signature, mischievous grin, making one think it is most definitely someone we've already met. Any guesses?

According to another Grey's Anatomy source, McSteamy and Lexie Grey (Chyler Leigh) share a scene in episode three, which is shooting now.

He's single, she's single, he's McSteamy, she's Meredith's sister, the Grey girls love McDoctors ... Double McGrey wedding for the finale?

That's just one theory, of course. Now back to the gossip.

What are we to make of Shonda Rhimes' statement to TV Guide this week that "Izzie's (Katherine Heigl) got a love story — and it's a big one, one that I've been kicking around in my head for a bit, one that required me to take a huge leap of faith in myself, one that is so secret that I have not told anyone. Not the writers, not anyone."

Could that possibly mean an appearance by the daughter that Izzie gave up for adoption when she was a teen? E! says that storyline would be resurfacing at some point - and no one said "love story" means romance, right?

Lastly on the Grey's Anatomy spoiler front, many of the new medical stories this season will involve couples whose relationships could shed some light on that of Meredith (Ellen Pompeo) and Derek (Patrick Dempsey).

In one case, when a wife throws a remote control at her man, the resulting examination of his skull reveals a tumor. Expect Meredith to learn a little something by the end of this particular episode about arguments in long-term relationships that applies to fight night at the McMansion.

In particular, the lesson is, you know, "Use your words!"

What does everyone think of these potential spoilers? Share!

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.