Happy Birthday, Patrick Dempsey!

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The undisputed leading man of Grey's Anatomy, Patrick Dempsey, turns 43 today. Happy birthday, Patrick! The Maine native first rose to fame so long ago, many Grey's Anatomy fans probably aren't even familiar with what the star used to look like:

Young Patrick Dempsey

Hey, it was the late 1980s. We forgive McDreamy for the hair. While he was always a successful working actor, his second turn at stardom came early in 2005 when Derek Shepherd woke up in Meredith Grey's bed in the Grey's Anatomy pilot.

What a great ride it's been since.

Here's a little photo gallery of Patrick in honor of his big day. Click to enlarge!

Hunkiest TV Star Ever!
Patrick Dempsey Rides
What a McDreamy Individual
Too Sexy
A Pair of Stars
Young Pat
Senor Suave
Cover of E-Dubs
A Patrick Portrait
Race Car Drivin'
A Young Stud
Patrick & Jillian Dempsey at the Emmys
Sad Shepherd
Patrick & Jillian Dempsey
Patrick: Life Cover
It's Twins!
Patrick Dempsey Versace Ad
Jillian and Patrick Dempsey
Man of the Hour
Old Friends Again?
Hotness
Best Looks Ever
And Some MerDer Love Too
So, Come Here Often?

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.

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Happy birthday Patrick! You are like wine, the older, the better ♥

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Happy birthday!

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Happy Birthday Late
I have been a fan of yours for a long time. I also am an Avon Representative and is very excited about having your wife Jillian working with Avon. Congratulations also on your twins. That must keep you both very busy. God bless you.

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Feliz aniversario Patrick,voce é igual ao vinho,quanto mais velho melhor.Parabens!

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Happy Belated Birthday you sexy man!
I love McDreamy, amazing actor, keep up the good work!
Love you!

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For the photo:terrific hair!

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Happy birthday to the sexiest Capricorn on the planet.

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HAPPY BIRTHDAY MCDREAMY!!!!!!!!!!!!
i hpoe you feel better & healthy all the time!
YOU'RE AWESOME & GREAT! and what are your plans at 2009? AND BE THE HOTNESS GUY!!!!!

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HAPPY BIRTHDAY MCDREAMY!!!
I

Merder4ever

HAPPY (belated)BIRTHDAY PATRICK!! Another year and up another degree on the hotness scale! Stay beautiful!

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Grey's Anatomy Quotes

When we say things like "people don't change" it drives scientist crazy because change is literally the only constant in all of science. Energy. Matter. It's always changing, morphing, merging, growing, dying. It's the way people try not to change that's unnatural. The way we cling to what things were instead of letting things be what they are. The way we cling to old memories instead of forming new ones. The way we insist on believing despite every scientific indication that anything in this lifetime is permanent. Change is constant. How we experience change that's up to us. It can feel like death or it can feel like a second chance at life. If we open our fingers, loosen our grips, go with it, it can feel like pure adrenaline. Like at any moment we can have another chance at life. Like at any moment, we can be born all over again.

Meredith

Callie: Did anyone ever think you two were a couple?
Meredith: No, because we screw boys like whores on tequila.
Cristina: Then we either try to marry them or drown ourselves.
Callie: Huh.