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Tonight, Grey's Anatomy returns with an all-new episode (its 18th of the season), "Stand By Me." Check out the spoilers and previews posted earlier today for a primer!

Izzie Stevens' ailment is hard to keep secret, especially when the one person who knows is Cristina. Speaking of Yang, she is about to attempt her first solo surgery.

Oh, and there's the McDreamy matter. He's off in the woods, unable to find it within himself to return to work. He's fallen apart. Can anyone put him back together?

We can't wait to find out, and hear what you have to say about everything.

As always, you can discuss "Stand By Me" before, during and after the episode in our
Yang and Hunt

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.

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Grey's Anatomy Quotes

There's a reason I said I'd be happy alone. It wasn't 'cause I thought I'd be happy alone. It was because I thought if I loved someone and then it fell apart, I might not make it. It's easier to be alone, because what if you learn that you need love and you don't have it? What if you like it and lean on it? What if you shape your life around it and then it falls apart? Can you even survive that kind of pain? Losing love is like organ damage. It's like dying. The only difference is death ends. This? It could go on forever.

Meredith

You think that true love is the only thing that can crush your heart; that will take your life and light it up or destroy it. Then you become a mother.

Meredith