Tonight, Grey's Anatomy returns with an all-new episode (its 18th of the season), "Stand By Me." Check out the spoilers and previews posted earlier today for a primer!

Izzie Stevens' ailment is hard to keep secret, especially when the one person who knows is Cristina. Speaking of Yang, she is about to attempt her first solo surgery.

Oh, and there's the McDreamy matter. He's off in the woods, unable to find it within himself to return to work. He's fallen apart. Can anyone put him back together?

We can't wait to find out, and hear what you have to say about everything.

As always, you can discuss "Stand By Me" before, during and after the episode in our

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