Grey's Anatomy Preview: "What a Difference a Day Makes"

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Next Thursday, Grey's Anatomy turns 100 episodes young with a blockbuster wedding event. But will the long-awaited union of Meredith and Derek go off without a hitch?

Here's a preview of the episode, entitled "What a Difference a Day Makes." Despite her undying love for McDreamy, Mer is a little nervous about walking down the aisle ...

[video url="" title="What a Difference a Day Makes Sneak Preview #1"] [/video]

Elsewhere, Izzie's condition is bad, and getting worse. She's even experiencing familiar symptoms. Handsome symptoms, if you know what we mean. Know what we mean?

If not, click here for more preview clips ...

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.

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Grey's Anatomy Quotes

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)

Burke was- He took something from me. He took little pieces of me, little pieces over time, so small I didn't even notice, you know? He wanted me to be something I wasn't, and I made myself into what he wanted. One day I was me Cristina Yang, and then suddenly I was lying for him, and jeopardizing my career, and agreeing to be married and wearing a ring, and being a bride. Until I was standing there in a wedding dress with no eyebrows, and I wasn't Cristina Yang anymore. And even then, I would've married him. I would have. I lost myself for a long time. And now that I'm finally me again, I can't. I love you. I love you more than I loved Burke. I love you. And that scares the crap out of me because when you asked me to ignore Teddy's page, you took a piece of me, and I let you. And that will never happen again.