Grey's Anatomy has prescribed an encore for Mitch Pileggi.

Pileggi, who first guest-starred on the ABC drama toward the end of Season Three (remember him?), will be returning for the two-hour Season Six premiere, again playing hospital board chairman Larry Jennings, TV Guide has learned.

When Pileggi, an X-Files alum, first appeared as Jennings, the Seattle Grace bigwig required medical attention after a trip to the Amazon in South America left him with a carnivorous fish lodged in, well, an unfortunate part of his anatomy.

Now you remember him.

Larry Jennings is effectively a boss of Dr. Richard Webber (the Chief).

For his encore, Pileggi's hospital exec will have official business to tend to. It perhaps relates to not one but two staff members, Drs. Izzie Stevens and George O'Malley, currently on death's door as the new season begins. But that's just one of many possible theories.

Grey's Anatomy's season premiere airs Thursday, September 24, at 9 pm EST.

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.