Grey's Anatomy Spoilers: New Blood, New Beginnings

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Today's TV Guide spoiler Q&A focuses on a question many of us have been asking throughout the offseason as a "transitional" Grey's Anatomy begins to take shape: How will things change with some of its mainstays out of commission for significant periods of time?

Here's the latest dish on that, plus a bonus Private Practice item ...

Q: How will Grey's Anatomy write around the absences of Ellen Pompeo and Katherine Heigl?

A: The show will shift its focus to more character-centric episodes, executive producer Krista Vernoff says. One hour will be almost exclusively dedicated to Derek and a patient.

Seattle Grace's merger with Mercy West will bring in some new blood and cut loose some long-standing characters. Specific fallout from that plot line? That we'll have to wait for.

Bailey's in Charge

"There are some that stay [and] some that don't make it," says Chandra Wilson.

"There will be some familiar faces that remain ... but we also wanted the audience to be able to feel that this is a huge thing and that there was a loss there."

Q: Will Addison get a new love interest this season on Private Practice?

A: Kate Walsh answers this one: "I think we're holding off for a while," she says. "[Shonda Rhimes] is really interested in just seeing Addison single and running the practice with Sam." But that means more scenes with Taye Diggs - and more Taye Diggs is always a good thing, right?

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.

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Grey's Anatomy Quotes

There's a reason I said I'd be happy alone. It wasn't 'cause I thought I'd be happy alone. It was because I thought if I loved someone and then it fell apart, I might not make it. It's easier to be alone, because what if you learn that you need love and you don't have it? What if you like it and lean on it? What if you shape your life around it and then it falls apart? Can you even survive that kind of pain? Losing love is like organ damage. It's like dying. The only difference is death ends. This? It could go on forever.

Meredith

MEREDITH: "You don't get to call me a whore. When I met you, I thought I had found the person that I was going to spend the rest of my life with. I was done! All the boys and all the bars and all the obvious daddy issues, who cares? I was done. You left me. You chose Addison. I'm all glued back together now. I make no apologies for how I chose to repair what you broke. You don't get to call me a whore."
DEREK: "This thing with us is finished. It's over."
MEREDITH: "Finally."
DEREK: "Yeah, it's done."
MEREDITH: "It is done."