After taking a five-episode hiatus, Katherine Heigl will return to Grey's Anatomy for the show's January 21 episode. But will her on-screen husband be happy about it?

Izzie's absence has certainly affected Alex (Justin Chambers), who many believe may not be able to forgive his wife for walking out on him, according to TV Guide.

"Alex is just fed up," Chambers says.

"Alex is not built for all of this. He really meant what he said when he committed to her at their wedding and now he just feels it's all rushed too fast and he hasn't really necessarily thought everything through. He has so much emotional baggage anyway."

"Did he really do the right thing?" Justin Chambers wonders.

"Maybe he didn't. Does she really love him or does she love the idea of them? She's got so much to work out on her own, maybe they're not supposed to be together for a while, or ever."

Will they ultimately work through their differences? That remains to be seem, but things are going to get ugly when another woman is introduced.

According to insiders, a reeling Alex seeks solace at Joe's bar, where his inebriation, as it often does on the medical drama, sends him straight into a one-night stand.

"I was totally thrown off by it," Justin admits. "I think it's great though. It just adds a little spice to the show. The writers are really good at turning corners and taking your head for a little spin. It surprised me as much as it will the audience."

Any guesses as to who Alex's mystery woman is?

As for Heigl splitting time between the big and small screens in real life, Justin is more supportive. "Katherine is a movie star now," he says. "She's got such an exciting career going these days. I'm so happy for her. She's got to be a movie star."

Chambers says he personally has no plans to exit the show, and that given his personal situation, he'll stay at Seattle Grace as long as the producers will have him.

"This show is such a great springboard for all of us," he says. "I plan on having a career after this, but with my situation with my kids, this is the perfect job to have."

Justin and his wife Keisha have five (!) children - five big reasons why he's content working on one, L.A.-based show that doesn't involve too much travel.

"I love coming to work and I love the people I work with. On hiatus, I've taken advantage of a lot of free time with my family. I definitely like my job. I know what it's like to not know where you're going to work next and I don't want to go back to that."

We hope he doesn't have to!

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.