You may have heard the talk about a big breakup looming on Grey's Anatomy.

It's coming, there's no way around that. The only questions: Who and Why?

We know that it's "one of the longer-term, most-loved couples" on the medical drama, and that it's not necessarily the intrusion of a third party that does the job. So ... scratch Bailey and Ben, Alex and Lexie, and Mark and Teddy from the list based on that.

Which basically leaves us with three options: Meredith and Derek (unlikely), Cristina and Owen and Callie and Arizona (certainly possible). Who do you think breaks up?

Vote in our survey below, and feel free to leave a comment elaborating ...

Everyone eagerly awaits the answer to this one.

Who breaks up on Grey's Anatomy?

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.