Who Will Break Up on Grey's Anatomy?

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You may have heard the talk about a big breakup looming on Grey's Anatomy.

It's coming, there's no way around that. The only questions: Who and Why?

We know that it's "one of the longer-term, most-loved couples" on the medical drama, and that it's not necessarily the intrusion of a third party that does the job. So ... scratch Bailey and Ben, Alex and Lexie, and Mark and Teddy from the list based on that.

Which basically leaves us with three options: Meredith and Derek (unlikely), Cristina and Owen and Callie and Arizona (certainly possible). Who do you think breaks up?

Vote in our survey below, and feel free to leave a comment elaborating ...

Listening to the Boss

Everyone eagerly awaits the answer to this one.

Who breaks up on Grey's Anatomy?

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.

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Grey's Anatomy Quotes

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)

MEREDITH: "You don't get to call me a whore. When I met you, I thought I had found the person that I was going to spend the rest of my life with. I was done! All the boys and all the bars and all the obvious daddy issues, who cares? I was done. You left me. You chose Addison. I'm all glued back together now. I make no apologies for how I chose to repair what you broke. You don't get to call me a whore."
DEREK: "This thing with us is finished. It's over."
MEREDITH: "Finally."
DEREK: "Yeah, it's done."
MEREDITH: "It is done."