Who Will Break Up on Grey's Anatomy?

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You may have heard the talk about a big breakup looming on Grey's Anatomy.

It's coming, there's no way around that. The only questions: Who and Why?

We know that it's "one of the longer-term, most-loved couples" on the medical drama, and that it's not necessarily the intrusion of a third party that does the job. So ... scratch Bailey and Ben, Alex and Lexie, and Mark and Teddy from the list based on that.

Which basically leaves us with three options: Meredith and Derek (unlikely), Cristina and Owen and Callie and Arizona (certainly possible). Who do you think breaks up?

Vote in our survey below, and feel free to leave a comment elaborating ...

Listening to the Boss

Everyone eagerly awaits the answer to this one.

Who breaks up on Grey's Anatomy?

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.

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Grey's Anatomy Quotes

There's a reason I said I'd be happy alone. It wasn't 'cause I thought I'd be happy alone. It was because I thought if I loved someone and then it fell apart, I might not make it. It's easier to be alone, because what if you learn that you need love and you don't have it? What if you like it and lean on it? What if you shape your life around it and then it falls apart? Can you even survive that kind of pain? Losing love is like organ damage. It's like dying. The only difference is death ends. This? It could go on forever.

Meredith

You think that true love is the only thing that can crush your heart; that will take your life and light it up or destroy it. Then you become a mother.

Meredith