Katherine Heigl is gone from Grey's Anatomy, but not forgotten.

This is particularly true for her co-star and on-screen husband.

"I miss her all the time," Justin Chambers told E! at the Maui Film Festival. "Katherine's such a great actor. She's so fun to work off of. I really miss working with her."

We've seen the last of their on-screen romance ... but we haven't heard the last of it. As we know, Alex called out for Izzie when he was shot in the Season Six finale.

"I think that's a couple on TV that people will always remember," he said. "There's not much Alex without her. I think he'll be mourning Izzie for the next two seasons."

Katherine Heigl's exit from Grey's Anatomy was an ongoing saga.

Chambers also defended his friend, who was originally due to return in the second half of this past season but ultimately did not, against her many critics in the press.

"She admits that she has a mouth on her, but she's got a heart that's much bigger than her mouth," he said. "It's unfair because I think people have taken her the wrong way."

"She's actually a good person. She's very funny and very kind."

Do you miss Izzie? Should the show continue to explore Alex's feeling for her next season, or have him make a clean break emotionally? Discuss.

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.