Are you ready for the most devastating House episode of the season, fans?

On February 7, the patient of the week won't be a random individual who we meet in the opening minute, gets cured by the team within an hour and is never hear from again. Instead, it will be Cuddy's mom.

What, exactly, is her ailment? We don't know. But in one of the clips below, House surmises that it may be related to her intake of alcohol. Check out the sneak peeks now and prepare for an intense installment.

Matt Richenthal is the Editor in Chief of TV Fanatic. Follow him on Twitter and on Google+.