Grey's Anatomy has played the miscarriage card before. Is Callie headed for a similar tragedy in the wake of the car accident that set the stage for this week's episode?

Obviously, the question of whether her unborn child with Mark will survive the accident is a major question of the musical event that has been hyped for weeks on end.

Will Callie and the baby make it? Here's what Sara Ramirez had to say:

Sara in the studio prepping for her biggest episode yet.

"Maybe Callie getting pregnant with Mark's child isn't really an accident in the bigger picture," the Tony winner teased to TV Guide. "This child may teach Callie, Arizona, and Mark something they had no idea they needed to learn and grow from."

What do you think she means by that? Will tragedy strike? Or will they all come out of this fine, with a renewed commitment to their unconventional family unit?

Comments and theories are welcomed below ...

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.