“God Laughs.”

Apparently, something or several things take place during the fifth season premiere that make the doctors of Private Practice think the man upstairs is amused.

Or just being cruel. The opening minutes September 22 reportedly pick up where the fourth season finale left off, with Pete on the ground and only Lucas nearby.

What is God laughing at? What game-changers await?

What do you make of - and expect from - this curiously-titled episode Private Practice, which returns after a two-hour Grey's Anatomy? Share your theories below!

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.