April calling the shots. That's a concept that's going to require some adjusting to - for April and everyone else.

In the third episode of the fall (September 29, one week after next Thursday's two-part premiere), The Chief makes a big career-changing decision, Cristina and Owen try to find normalcy, and April continues to struggle in her new role as Chief Resident, which was almost a foregone conclusion.

Meanwhile, the fifth year residents are at last given their first solo surgeries, only to find out that even the most routine procedures aren't always easy. The title of this episode, fittingly, is "Take the Lead."

Stills from the episode appear below. If you missed them, check out our season premiere photos as well!

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.