It's the beginning of the end for Cristina Yang.
No, this character isn't dying, Shonda Rhimes has been clear about that.
But the journey toward her farewell kicks off on Grey's Anatomy Season 10 Episode 21, as teased in the following preview. Prepare many boxes of Kleenex and view now:
Elsewhere on "Change of Heart," fans can expect Bailey to make a risky decision; Richard to surprise Catherine in Boston; Jackson to deliver bad news; and Amelia to pay a visit to her brother.
Watch Grey's Anatomy online to relive some of your favorite Cristina moments and check out episodic images now for a look ahead: