The Derek Shepherd smirk will leave on forever and ever in the hearts and minds of Grey's Anatomy fans.

Derek gets the double high-five request in "Readiness is All."

Derek and Owen in a photo from "Transplant Wasteland." The episode airs March 14, 2012.

Derek looking handsome as ever in a photo from "Transplant Wasteland." The episode airs March 14, 2012.

Meredith and Derek in bed on Grey's Anatomy!

Derek shares a double high-five in the May 9, 2013 episode of Grey's Anatomy, "Readiness is All."

Wait... huh? Who?!? What?!? Derek and Meredith are a tad taken aback in this Grey's Anatomy scene.

Veronica Cartwright guest stars here on Grey's Anatomy. As you can see, she plays a patient of Derek's.

Does it get any sweeter than this? Derek holds his child as Meredith looks on.

Derek and the baby in a shot from Grey's Anatomy's third episode of Season 10.

It's Derek vs. Meredith! These two did not end Grey's Anatomy Season 10 on a positive note.

Derek and Amelia are having some issues on Grey's Anatomy. They are not getting along professionally in any way, shape or form.

Derek, Meredith and Zola in a scene from this week's Grey's Anatomy episode, "This is Why We Fight."

Derek looks on in this scene from Grey's Anatomy Season 11. It's from the episode "Can We Start Again Please?"

Derek looks satisfied with his results on Grey's Anatomy. "Map of You" is the sixth episode of the show's tenth season.

Did Derek get the results he expected on Grey's Anatomy. "Map of You" is the sixth episode of the show's tenth season.

Derek looks like he's enjoying his new project on Grey's Anatomy. "Map of You" is the sixth episode of the show's tenth season.

Derek and Shane work together on a brain mapping project on Grey's Anatomy. "Map of You" is the sixth episode of the show's tenth season.

Ben and Derek collaborate on a new technique on Grey's Anatomy. "Thriller" is the seventh episode of the show's tenth season.

Derek gets news that could change things on Grey's Anatomy. "Get Up, Stand Up" is the 12th episode of the show's tenth season.

Meredith and Derek in a scene from the May 9, 2013 episode of Grey's Anatomy, "Readiness is All."

Derek and Owen in a photo from "Transplant Wasteland." This Grey's Anatomy episode airs March 14, 2013.

Derek had to bring the baby in to work on Grey's Anatomy. "Get Up, Stand Up" is the 12th episode of the show's tenth season.

Derek gets an offer that could change everything on Grey's Anatomy. "Get Up, Stand Up" is the 12th episode of the show's tenth season.

It's like Derek is smiling into our soul in this Grey's Anatomy image, isn't it?

When someone falls to the floor, Derek and Owen fight to save a life in "Do You Know?"

Dr. Derek Shepherd in "Transplant Wasteland."

The only couple on this list who actually hooked up prior to the series ever starting, Grey's Anatomy kicked off the morning after Meredith and Derek went home from a bar together. Sure, he was married at the time - but that technicality was no match in the end for (sorry we have to say it...) the McDreamiest pairing on all of television.

Amelia is back on Grey's Anatomy. And she's working here with Derek.

This is a nice Meredith and Derek moment, isn't it? Some Grey's Anatomy fans say we don't see enough of these anymore.