Eric Murphy, aka "E", is Vince's best friend and manager.  Eric moves with Vince to Los Angeles and starts off as a manager at Sbarro's until Vince's career takes off and is able to make it as his manager.  Since then E has gone on to start his own management company, The Murpy Group, and has expanded to multiple clients.

Eric "E" Murphy Quotes

Johnny "Drama" Chase: We don't wanna tell you she's a bitch, then two weeks later you get back together and you're mad at us for saying that.
Eric Murphy: It's over.
Drama and Turtle: She's a bitch!

Turtle: Kristin's fucking Vince Vaughn!
Eric: What are you talking about? She's back with that restaurant guy...
Turtle: She was in the middle of 40 Deuce with her hands down Vince Vaughn's pants.
Eric: She had her hands down his pants?!
Drama: Yeah, both of 'em.
Eric: Vince Vaughn?! That puffy motherfucker?!
Drama: Nah, bro, he didn't look puffy at all. He was looking real good.
Turtle: Yeah, it was kinda like "Swingers" Vince Vaughn, not Old School Vince Vaughn... it's kinda like New School Vince Vaughn