Janice Soprano is Tony's tragic excuse for an older sister on The Sopranos.  She doesn't seem to have much luck with men as they all some to end up dead.

Janice Soprano Quotes

Tony: I'm sellin' Ma's house. You understand, Janice? Now put that fucking sign back in the fucking ground and that's it. End of discussion. Period.
Janice: You're so left brained. Whether the sign is there or not, the house is still for sale. The agent still has the listing.

Some family reunion--the woman who bore them all is barred from the premises.

Janice
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The Sopranos Quotes

(to Mahaffey) That's a shame. A medication comes along after your gambling gets your fucking hip busted to shit.

Big Pussy

Dr. Melfi: Have you ever had a prostate exam?
Tony: Are you kidding? I don't let anyone wag their finger in my face.