Lois Lane (Erica Durance) was introduced in season four of Smallville when she comes to investigate the mruder of her cousin, Chloe Sullivan.  However, when she finds out Chloe is still alive, she enrolls in Smallville High to finish the high school degree she never did.

As of season seven, Lois has been a reporter for The Daily Planet.  Though her and Clark often butt heads and love to tease each other, there's definitely going to be a Lois and Clark in the future.  Duh, have you read the comics?

Lois Lane Quotes

Lois: Who the hell are you, then?
John Corben: I'm a field reporter. I spent the last few years in Afghanistan. hopefully that gave me enough training to be your desk mate.
Lois: Don't bet on it.

John Corben: Good find?
Lois: Look, on a scale of 1 to 10 of illegal things I've done in my life, this doesn't even hit the radar. Okay, that didn't exactly come out right.

Smallville Quotes

I'm about as real as it gets.

Chloe

Clark: My father says you learn more about yourself when you lose.
Lex: What'd you learn?
Clark: That I'm not destined to be a politician. You need two different personalities.
Lex: You don't need to be an elected official to change the world, Clark.
Clark: Have you ever thought about getting into politics?
Lex: Someday I'd like to be president.