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I would absolutely hate it if Dair happened. They might as well make Serena and Chuck get together if friendships and former relationships don't matter. GG has to do something else rather than make everyone hook-up with each other.
For me, the best scenes of the episode were the one between Meredith and Owen (their confrontation) and when Cristina was holding the trout. They both seem monumental and I just feel like they're the gateway to the rest of these characters' journeys.
And I'm really looking forward to seeing how Mark & Lexie and Callie & Arizona will go. Right now they seem to be the only developing love stories of the show.