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as much as i hate katherine heigl for leaving the show, and as much as the show had a super amazing cast in season 2, izzie is what made season 2, especially the finale so incredibly epic. when i think of grey's, what first comes to mind is izzie and denny and LVAD wires :P. she gave season 2 that unpredictability and great acting. but i am so sad, and it is certain that she will never EVER come back to the show. and i do not think that shonda would kill her off, and i dont think that she will provide closure. Shonda has a tendency to write off characters in such a terrible and unfinished way. remember erica hahn? or sadie? the same will be with katherine heigl, the divorce papers were probably the last thing we will hear of her and alex.
I totally agree with @amelia and @talkingTalk. Katherine Heigl is an amazing actress and did a fantastic job portraying the one and only Izzie Stevens. I hope that Shonda provides us with some closure but i definately wont be holding me breath...