The only couple on this list who actually hooked up prior to the series ever starting, Grey's Anatomy kicked off the morning after Meredith and Derek went home from a bar together. Sure, he was married at the time - but that technicality was no match in the end for (sorry we have to say it...) the McDreamiest pairing on all of television.
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Whatever's going on, Derek looks very serious on Grey's Anatomy.
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When someone falls to the floor, Derek and Owen fight to save a life in "Do You Know?"
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It's like Derek is smiling into our soul in this Grey's Anatomy image, isn't it?
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Unfortunately for McDreamy, Meredith may be the one person who isn't awed by his big news in "Take It Back"
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Everyone wants Derek, even the President of the United States is giving him a call on Grey's Anatomy.
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Derek gets an offer that could change everything on Grey's Anatomy. "Get Up, Stand Up" is the 12th episode of the show's tenth season.
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Derek had to bring the baby in to work on Grey's Anatomy. "Get Up, Stand Up" is the 12th episode of the show's tenth season.
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Derek gets news that could change things on Grey's Anatomy. "Get Up, Stand Up" is the 12th episode of the show's tenth season.
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Owen looks bored with whatever is being said in this meeting on Grey's Anatomy. "Get Up, Stand Up" is the 12th episode of the show's tenth season.
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What were Owen and Derek called in for on Grey's Anatomy? "Get Up, Stand Up" is the 12th episode of the show's tenth season.
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Ben and Derek collaborate on a new technique on Grey's Anatomy. "Thriller" is the seventh episode of the show's tenth season.
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Grey's Anatomy Quotes

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)

There's a reason I said I'd be happy alone. It wasn't 'cause I thought I'd be happy alone. It was because I thought if I loved someone and then it fell apart, I might not make it. It's easier to be alone, because what if you learn that you need love and you don't have it? What if you like it and lean on it? What if you shape your life around it and then it falls apart? Can you even survive that kind of pain? Losing love is like organ damage. It's like dying. The only difference is death ends. This? It could go on forever.

Meredith