The only couple on this list who actually hooked up prior to the series ever starting, Grey's Anatomy kicked off the morning after Meredith and Derek went home from a bar together. Sure, he was married at the time - but that technicality was no match in the end for (sorry we have to say it...) the McDreamiest pairing on all of television.
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Whatever's going on, Derek looks very serious on Grey's Anatomy.
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When someone falls to the floor, Derek and Owen fight to save a life in "Do You Know?"
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It's like Derek is smiling into our soul in this Grey's Anatomy image, isn't it?
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Unfortunately for McDreamy, Meredith may be the one person who isn't awed by his big news in "Take It Back"
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Everyone wants Derek, even the President of the United States is giving him a call on Grey's Anatomy.
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Derek gets an offer that could change everything on Grey's Anatomy. "Get Up, Stand Up" is the 12th episode of the show's tenth season.
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Derek had to bring the baby in to work on Grey's Anatomy. "Get Up, Stand Up" is the 12th episode of the show's tenth season.
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Grey's Anatomy Quotes

We're all going to die. We don't get much say over how or when, but we do get to decide how we're gonna live. So, do it. Decide. Is this the life you want to live? Is this the person you want to love? Is this the best you can be? Can you be stronger? Kinder? More Compassionate? Decide. Breathe in. Breathe out and decide.

Richard

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)