In this photo from the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," Dr. Derek Shepherd (Patrick Dempsey) appears to be in a heated debate with Dr. Owen Hunt (Kevin McKidd).
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Derek Shepherd looks on with those amazing eyes in the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me." But will McDreamy by okay in this episode?
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In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," Derek Shepherd looks as handsome as ever. But will he be involved in the major car wreck shown at the beginning?
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In this photo from the fourth season finale of Grey's Anatomy, "Freedom," Meredith and Derek continue work on their clinical trial... and the trials of their own lives.
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In this photo from the fourth season finale of Grey's Anatomy, "Freedom," Derek, Mark and Richard are seen in a rare scene outside Seattle Grace. Where is it?
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In this photo from the fourth season finale of Grey's Anatomy, "Freedom," Derek gives Meredith that look he's known for. How can anyone possibly resist?
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In this photo from the fourth season finale of Grey's Anatomy, "Freedom," Meredith and Derek hash things out. Will Meredith achieve "freedom" from her demons?
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In this photo from the fourth season finale of Grey's Anatomy, "Freedom," Meredith and Derek discuss their clinical trial... and figure out their lives. Hopefully.
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Grey's Anatomy Quotes

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)

I want to marry you. I want to have kids with you. I want to build us a house. I want to settle down and grow old with you. I want to die when I'm 110 years old, in your arms. I don't want 48 uninterrupted hours. I want a lifetime. Mmm. Do you see what happens? I say things like that and you fight the urge to run in the opposite direction. It's okay, I understand. I didn't, but now I do, I do. You're just getting started and I've been doing this for a long time now. Deep down, you're still an intern, and you're not ready.

Derek