Nope, it just doesn't work. Go away Rose! She probably will leave our Der alone... at least that's what Grey's Anatomy spoilers have indicated. She looks to be a factor in this episode #12 of Grey's Anatomy's fourth season, though.
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Always a fan favorite, Derek Shepherd poses for the camera.
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Derek and Miranda talk as a patient's life hangs in the balance in "Forever Young," from Season Four of Grey's Anatomy.
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Derek Shepherd and Miranda Bailey discuss the day's events on "Forever Young," the episode from Grey's Anatomy's 4th season, airing originally on November 15, 2007.
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Drs. Shepherd, Yang and Grey (the younger) consult with a man about an important medical decision to be made. From "Physical Attraction, Chemical Reaction."
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Derek Shepherd (Patrick Dempsey), Lexie Grey (Chyler Leigh) and Cristina Yang (Sandra Oh) in the episode called "Physical Attraction, Chemical Reaction," from Season Four of Grey's Anatomy.
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Derek and Lexie discuss a case with a patient and other staff members. We like these two together... so long as there's no romance involved!
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Derek Shepherd (Patrick Dempsey) constantly desires more than Meredith (Ellen Pompeo) is willing to give. How long until he reaches his breaking point.
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Grey's Anatomy Quotes

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)

I want to marry you. I want to have kids with you. I want to build us a house. I want to settle down and grow old with you. I want to die when I'm 110 years old, in your arms. I don't want 48 uninterrupted hours. I want a lifetime. Mmm. Do you see what happens? I say things like that and you fight the urge to run in the opposite direction. It's okay, I understand. I didn't, but now I do, I do. You're just getting started and I've been doing this for a long time now. Deep down, you're still an intern, and you're not ready.

Derek