Nope, it just doesn't work. Go away Rose! She probably will leave our Der alone... at least that's what Grey's Anatomy spoilers have indicated. She looks to be a factor in this episode #12 of Grey's Anatomy's fourth season, though.
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Always a fan favorite, Derek Shepherd poses for the camera.
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Derek and Miranda talk as a patient's life hangs in the balance in "Forever Young," from Season Four of Grey's Anatomy.
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Derek Shepherd and Miranda Bailey discuss the day's events on "Forever Young," the episode from Grey's Anatomy's 4th season, airing originally on November 15, 2007.
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Drs. Shepherd, Yang and Grey (the younger) consult with a man about an important medical decision to be made. From "Physical Attraction, Chemical Reaction."
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Derek Shepherd (Patrick Dempsey), Lexie Grey (Chyler Leigh) and Cristina Yang (Sandra Oh) in the episode called "Physical Attraction, Chemical Reaction," from Season Four of Grey's Anatomy.
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Derek and Lexie discuss a case with a patient and other staff members. We like these two together... so long as there's no romance involved!
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Derek Shepherd (Patrick Dempsey) constantly desires more than Meredith (Ellen Pompeo) is willing to give. How long until he reaches his breaking point.
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Grey's Anatomy Quotes

Just because we can live without something, it doesn't mean we have to.

Meredith

Derek: I am calling post-it, Zola, Bailey, the tumors on the wall, ferryboat scrub caps. I thought D.C. was everything. I was wrong. You... you're everything. I love you and I'm not going to stop loving you. I can't live without you. I don't want to live without you, and I'm going to do everything in my power to prove it.
Meredith: I can live without you, but I don't want to. I don't ever want to.