Izzie and George in "What a Difference a Day Makes," from the fifth season of Grey's Anatomy. The emotional wedding scene was one for all time.
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Izzie stumbled on her way down the aisle, but George stepped in and helped his old friend make it to the steps, where she exchanged vows with Alex. Tear.
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It was a sweet scene when George gave away Izzie to Alex at the wedding, when she became weak and could not walk under her own power. Tears were shed at this website.
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George and Owen at the wedding of Alex and Izzie. These two make a great trauma surgeon team, as we've seen in recent weeks.
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Alex and George look upward as a patient prepares to take the plunge ... and not the kind you want to see them take.
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Meredith and George (he lives!) in a promotional photo from "Elevator Love Letter."
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Meredith, Cristina and George in a photo from "Elevator Love Letter."
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Remember Gizzie? As in George and Izzie? You can be forgiven if you don't, but here they are in a cute, recent photo.
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George sighting! George sighting! Will O'Malley actually have a central role in this episode? Here's hoping.
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A picture of Lexie and George, talking things out. Do we think she still wants him after she blew up at him the last time? We'll see...
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Well, not that kind of action. But there's a lot of activity in this photo from "There's No 'I' in Team," from Season Five of Grey's Anatomy, as the residents discuss their respective days.
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George O'Malley is now a resident at long last! How will he respond now that he has interns? Here's our guy in this photo from "There's No 'I' in Team," from Season Five of Grey's Anatomy.
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Grey's Anatomy Quotes

There's a reason I said I'd be happy alone. It wasn't 'cause I thought I'd be happy alone. It was because I thought if I loved someone and then it fell apart, I might not make it. It's easier to be alone, because what if you learn that you need love and you don't have it? What if you like it and lean on it? What if you shape your life around it and then it falls apart? Can you even survive that kind of pain? Losing love is like organ damage. It's like dying. The only difference is death ends. This? It could go on forever.

Meredith

MEREDITH: "You don't get to call me a whore. When I met you, I thought I had found the person that I was going to spend the rest of my life with. I was done! All the boys and all the bars and all the obvious daddy issues, who cares? I was done. You left me. You chose Addison. I'm all glued back together now. I make no apologies for how I chose to repair what you broke. You don't get to call me a whore."
DEREK: "This thing with us is finished. It's over."
MEREDITH: "Finally."
DEREK: "Yeah, it's done."
MEREDITH: "It is done."