Izzie, Alex and Cristina at George's funeral. We will see this unfold when the new season of Grey's Anatomy airs.
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Alex reacts as Izzie slips away from him, possibly for the last time.
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Is Izzie about to slip away into the afterlife?
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Alex calls for help as Izzie fades into unconsciousness.
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Cristina and Izzie share a moment in "Now or Never."
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Izzie Stevens crashes at the end of "Now or Never." Will she live?
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Alex and Izzie don't know what the best course of action is going forward, and it's hard to blame them.
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Izzie and Alex embrace in the fifth season finale.
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Grey's Anatomy Quotes

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)

Derek: I am calling post-it, Zola, Bailey, the tumors on the wall, ferryboat scrub caps. I thought D.C. was everything. I was wrong. You... you're everything. I love you and I'm not going to stop loving you. I can't live without you. I don't want to live without you, and I'm going to do everything in my power to prove it.
Meredith: I can live without you, but I don't want to. I don't ever want to.