Izzie, Alex and Cristina at George's funeral. We will see this unfold when the new season of Grey's Anatomy airs.
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Alex reacts as Izzie slips away from him, possibly for the last time.
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Is Izzie about to slip away into the afterlife?
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Alex calls for help as Izzie fades into unconsciousness.
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Cristina and Izzie share a moment in "Now or Never."
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Izzie Stevens crashes at the end of "Now or Never." Will she live?
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Alex and Izzie don't know what the best course of action is going forward, and it's hard to blame them.
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Izzie and Alex embrace in the fifth season finale.
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Grey's Anatomy Quotes

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)

I want to marry you. I want to have kids with you. I want to build us a house. I want to settle down and grow old with you. I want to die when I'm 110 years old, in your arms. I don't want 48 uninterrupted hours. I want a lifetime. Mmm. Do you see what happens? I say things like that and you fight the urge to run in the opposite direction. It's okay, I understand. I didn't, but now I do, I do. You're just getting started and I've been doing this for a long time now. Deep down, you're still an intern, and you're not ready.

Derek