Penny meets Raj and Wolowitz in the pilot episode of The Big Bang Theory. Wolowitz will begin his lifetime of sleazily hitting on her while Wolowitz is unable to talk to her.
Sheldon [to Kripke]: Also, I am given to understand that your mother is overweight. Raj: Oh, snap. Sheldon: Now of course, if that is the result of a glandular condition and not sloth and gluttony then I withdraw that comment.
