An old promotional photo of Blair and Serena. How cute do they look here!

Lola and Serena in a photo from the April 16, 2012 episode of Gossip Girl, "Salon of the Dead."

In a scene from "The Blair Bitch Project," from the first season of Gossip Girl, Blair Waldorf (Leighton Meester) and Serena van der Woodsen (Blake Lively) and have a conversation. They make a very cute pair of pals, they do.

A scene from "The Blair Bitch Project," from the first season of Gossip Girl. Jenny Humphrey is running the social show now that Blair Waldorf has been dethroned, and Serena is comforting Blair, or at least doing her best for her friend.

Cate is seen here with her daughter. The character is distressed to learn, in the pilot, that Lux has grown up in foster homes.

Flanked by bridesmaids and groomsmen, Kate Walsh and Alex Young celebrate their wedding day. For the couple, September 1, 2007, will always remain in their hearts.

Serena in a striped outfit on Gossip Girl. She's always so stylish.

In a scene from "Desperately Seeking Serena," from the first season of Gossip Girl, Georgina Sparks (Michelle Trachtenberg) returns to stir up trouble for Serena (Blake Lively). What will transpire when these former BFFs and current enemies collide?

In a photo from "Much I Do About Nothing," the first-season finale of Gossip Girl, Lily prepares to walk down the aisle with Bart as Serena looks on.

The 90210 cast goofs around on set. Elder statesmen Lori Loughlin and Rob Estes get touched up by make up artists.

Blair with Eleanor, Dorota and Serena.

Okay, so that was a bit of a stretch. But there is little doubt that Gossip Girl's Serena van der Woodsen (Blake Lively) has a beautiful smile.