Sam wants to prevent Anna from carrying out her mission on the episode "The Song Remains The Same." That's because her mission is to stop Sam from ever being born.

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Photo Credit:
The CW
Show:
Supernatural
Episode:
Supernatural Season 5 Episode 13: "The Song Remains The Same"
Character:
Sam Winchester
Related Photos:
Supernatural Photos, Supernatural Season 5 Episode 13 Photos, Sam Winchester Photos
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Supernatural Season 5 Episode 13 Quotes

Dean: What exactly are we gonna march up there and tell 'em?
Sam: Uh, the truth.
Dean: What, that their sons are back from the future to save them from an angel gone Terminator? Come on, those movies haven't even come out yet.

Dean: Really? Anna?
Castiel: It's true.
Dean: So she's gone all Glenn Close, huh? That's awesome.
Castiel: Who's Glenn Close?
Dean: No one. Just this psycho bitch who likes to boil rabbits.
Sam: So, the... the plan to kill me--would it actually stop Satan?
Dean: No, Sam, come on.
Sam: Cass, what do you think? Does Anna have a point?
Castiel: No. She's a... "Glenn Close."