When Peter goes back in time and messes things up with Lois, she ends up marrying Quagmire and having a Chris, Meg and Stewie that look like Quagmire instead.

Family Guy Season 5 Episode 18 Quotes

Lois: Peter used to be so passionate, but now he doesn't seem to be interested in me.
Quagmire: Lois, if I may, Peter doesn't you. As a friend, I think you deserve to be with someone who knows how to be a gentleman.
Lois: Oh, Glen. You're so sweet. (They embrace) Something's poking me.
Quagmire: It's alright. It's just my wang.

Lois: Peter, what are you doing?
Peter: I love you, Lois Pewterschmidt! And I won't let Quagmire, or any man, she-male, robot, or sentient robot, curious about it's own existence keep us apart!