Meredith is on the war path. She has been scarred by the Grey's Anatomy plane crash.

Meredith and Derek share a sexy moment in "Here Comes the Flood," the third episode from Season 5 of Grey's Anatomy. We can't wait to see their relationship evolve and grow.

Awww, look at this happy family! Meredith walks around with her kids in this scene from Grey's Anatomy.

Meredith is in mourning on Grey's Anatomy, and for good reason: her husband is now dead.

Meredith deals with a young patient in this scene from Grey's Anatomy. It's from "Mama Only Knows," Episode 4 of Season 11.

Meredith Grey in the Season 9 premiere of Grey's Anatomy.

Meredith finds something of Derek's on Grey's Anatomy.

Her face says it all. The loss of her husband is sinking in for Meredith Grey.

The only couple on this list who actually hooked up prior to the series ever starting, Grey's Anatomy kicked off the morning after Meredith and Derek went home from a bar together. Sure, he was married at the time - but that technicality was no match in the end for (sorry we have to say it...) the McDreamiest pairing on all of television.

Nico is all in when he tells Levi that he loves him and wants to be with him for real this time after everything;.

Meredith gathers her things and her children before leaving to go... somewhere.

Meredith has a lot to deal with on the Grey's Season 11 premiere. Notice she's without Derek in all these photos.