George and Izzie will always be close, even though their relationship has been through its ups and downs. What a wonderfully-written scene this was, when he helped her down the aisle.
Alex and Izzie kiss after they are pronounced husband and wife. What an emotional, wonderful episode in every sense.
The big wedding finally took place - and it wasn't the people who were scheduled to get married on this date and in that venue. But it was still magical.
Izzie Stevens prepares to wed Alex Karev in "What a Difference a Day Makes," the 100th episode of Grey's Anatomy. What a beautiful bride she made.
Izzie and George in "What a Difference a Day Makes," from the fifth season of Grey's Anatomy. The emotional wedding scene was one for all time.
Meredith Grey was slated to get married on this day. But Izzie's condition and her having planned the dream wedding led the gang to suggest that she and Alex get married instead.
Meredith, that is. Yup, Alex requested her services as he married Izzie on the show's 100th episode. She looked terrific, too.
Cristina Yang was Izzie's maid of honor at her wedding to Alex. This was a very sweet scene on the show's 100th episode.

Grey's Anatomy Season 5 Episode 22 Quotes

Cristina: You slept here?
Callie: I'm awake. What?
Cristina: You slept here? I slept here!
Callie: Um, how? Wait... who? What?
Cristina: I slept in the on call room.
Callie: Oh.
Cristina: I could have been at home in my own bed.
Callie: Sorry.
Cristina: Now I have to work all day, and then I have to be happy maid of honour and get Meredith down the aisle. I'm so tired, 'cause I slept here! 'Cause you wanted to get your freak on with roller skate girl.
Callie: I am sorry. I was gonna, but, we went to dinner and, things didn't... I wasn't in the mood. I had to be here early anyway, to run the ER, so...
Cristina: Oh, you're picking up extra shifts in the ER? So is ah, is Owen not here today?
Callie: Ah, he's here. Oh crap! I'm late. Hey.
Meredith: Hey.
Cristina: BIG DAY! Biggest day of your life!
Meredith: Don't do that! Don't do the peppy maid of honour thing, it's creepy!
Cristina: Really? Good. Wait... is this like the calm before the storm? Do you need me to drug you? Or shave of your eyebrows to numb you into submission?
Meredith: No! I'm fine. It's not the biggest day of my life. It's the biggest day of Izzie's life. I'm excited about the marriage, not some wedding. Anyway, she's the one that's gone all bridezilla.
Cristina: Briiiideeezillaaaaaaaaa...

Meredith: Just a normal day.
Derek: Normal day. Going to work.
Meredith: Just a normal day, that ends in a ceremony in a churchy church.
Derek: This has nothing to do with us, we're just the bride and groom.
Meredith: We're getting married tonight.
Derek: We're getting married tonight (smiles)
Meredith: (smiles back)