In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," Meredith and Miranda attend to a will-be patient after a crash.

It's coming to Seattle Grace, but what else is new? In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," a car wreck sends several memorable patients to the OR.

In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," a crash shakes things up at Seattle Grace. Major trauma - and drama.

At least it looks like that's what Miranda and Meredith are yelling. In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," the two doctors look on as something shocking happens.

It looks like that's about to happen in the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," which we see a scene from here.

At least Izzie seems to be. In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," Dr. Stevens and other doctors at Seattle Grace stand outside. What will happen next?!

In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," five of our favorite Seattle Grace staff members stand outside. Something tells us something bad is going to happen.

In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," four of our favorite Seattle Grace staff members stand outside their place of employment.

In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," Meredith Grey finds herself at a crossroads. Okay, that's every episode.

In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," Izzie helps a trauma patient out of the car. Looks intense!

Grey's Anatomy star Ellen Pompeo out and about in Hollywood in September 2008. She's the best.

Janina Gavankar will be guest starring on Grey's Anatomy this season, Entertainment Weekly reports. We look forward to it!