As Sam on Supernatural, Jared Padalecki has carved out quite a career for himself. He's seen here during the episode "99 problems."
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Supernatural Season 5 Episode 17 Quotes

Dean: 'Course, that's if you can get past the velvet rope. Must be nice--being chosen.
Leah: Well, Dean... you're chosen.
Dean: More like cursed.

No drinking, no gambling, no pre-marital sex. Dean, they basically just outlawed 90% of your personality.

Sam