In The Mentalist Season 1 Episode 23, "Red John's Footsteps" after declaring that he'd willingly die if it meant capturing Red John, Jane ends up shooting and killing the one man he knows could lead him to the serial killer in order to save Lisbon's life. Even Jane looks completely shocked by his actions.
Grace Van Pelt: Mr. Jane, I have a question regarding your previous career path. Patrick Jane: Fire away. Grace Van Pelt: When you met with other psychics, real psychics, could they tell you were just pretending? Patrick Jane: There's no such thing as real psychics.
Greetings old friend, it's been a while. I hope you are keeping well. I am thriving and happy. I have 12 wives now and will soon begin courting number 13. Why can't you catch me? You must feel so powerless and stupid and sad. Oh well. All the best. Red John.