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Susan and Katherine
It's come down for this for Susan and Katherine. They come to blows over Mike during the episode "Everybody Ought to Have a Maid."

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Desperate Housewives Photos, Susan Mayer Photos, Katherine Mayfair Photos
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Desperate Housewives Season 6 Episode 5 Quotes

Susan: Oh my God! Katherine, the gun just went off. Are you all right?
Katherine: You tried to kill me!
Susan: Okay, I just shot you. Let's not be throwing accusations around.

Laura, you're kind of a wet blanket since you quit smoking. Why don't you try a pipe?

Gabrielle