DEREK: "You really are Satan, you realize that right? If Satan were to take physical form he'd be you, everywhere. All the time."
ADDISON: "I am not Satan."
DEREK: "How come you haven't gotten on your broomstick and gone back to New York where you belong?"
ADDISON: "Stop being petty."
DEREK: "Stop being an adulterous bitch."
ADDISON: "You know there was a time when you though of me as your best friend."
DEREK: "There was a time that I thought you were the love of my life. Things change."

ADDISON: [interrupts Meredith and Derek kissing] "Well, isn't this cozy? Can I join in, or are you not in to threesomes?"
MEREDITH: "I have to go."

SAVANNAH: "I want my life. This gives me a shot, a shot at me and Weiss becoming this old wrinkled couple who argue all the time. Wouldn't you want that? A chance to grow old with Derek?"
ADDISON: [pauses] "Yeah. Yeah, I do."

[to Derek] "Medicine aside, our friends are going through hell in there, and we can't even act like we like each other long enough to help them."

[to Derek] "This whole thing brings back very traumatic memories of being a band geek, with braces and a lisp, spending the whole evening with Skippy Gold talking about Star Wars... So, do you want to dance?"

ADDISON: "I guess that puts an end to the evening."
DEREK: "Yeah."
RICHARD: "I guess it does." [Addison and Richard leave]
FINN: [to Meredith] "I'll drive you home."
DEREK: "Meredith." [Meredith, Finn and Derek all look at each other, exchanging knowing glances]
FINN: "Meredith..."

ADDISON: "Hey."
DEREK: "Hi."
ADDISON: "Where have you been?"
DEREK: "Oh, I was with..."

[the cast, narrating]
MEREDITH: "Human beings need a lot of things to feel alive."
GEORGE: "Family"
CRISTINA: "Love"
IZZIE: "Sex"
DEREK: "But we only need one thing"
RICHARD: "To actually be alive."
CRISTINA: "We need a beating heart."
ADDISON: "When our heart is threatened"
ALEX: "We respond in one of two ways."
GEORGE: "We either run or-"
IZZIE: "We attack."
RICHARD: "There's a scientific term for this."
ALEX: "Fight..."
ADDISON: "...or flight."
MIRANDA: "It's instinct."
MEREDITH: "We can't control it."
IZZIE: "Or can we?"

DEREK: "They just lost their daughter."
ADDISON: "I know. That's my point, Derek. They need to face that. She's not coming back."
DEREK: "A little sensitivity would be nice here, okay? They love their daughter. They don't want to let go. Alright?"

ADDISON: "I just have to ask... are you sleeping with my husband?"
MEREDITH: "Not since before I found out he was married."

ADDISON: "I know what you're going to say Richard, but if you knew the day I've had-"
RICHARD: "Everybody in this hospital has those days, Addison, and no one makes a scene in front of their peers. Get it together. [pauses] Addison?"
ADDISON: "I can't compete. He's not having an affair. He's not trying to hurt me. He's just... the only people who don't know that Derek loves Meredith are Derek and Meredith. How do I compete with that?"

DEREK: "What do you want from me, Addison?"
ADDISON: "I want you to care. I sleep with your best friend, and you walk away. Then he comes out here from New York and rubs it in your face, and you still get a good night's sleep. What do I have to do? Oh, I know. Maybe what I should do is go out on a date with the vet, because that seems to be something that sends you into a blinding rage. Oh, but wait. That won't work either because I'm not Meredith Grey."

Grey's Anatomy Quotes

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)

Derek: I wanna be with you forever, and you wanna be with me forever. In order to do that we need to make vows. A commitment. A contract. Give me a piece of paper.
Meredith: I don't! I... I... I don't. I have post its!
Derek: (takes the post its and a pen) Ok. What do we wanna promise each other?
Meredith: That you'll love me... even when you hate me.
Derek: To love each other, even when we hate each other. (writes it down) No running. Ever! (Mer smiles and comes and sits in front of him) Nobody walks out. No matter what happens.
Meredith: No running.
Derek: (writes it down) What else?
Meredith: That we'll take care of each other, even when we're old, and smelly, and senile. And... if I get Alzheimer's and forget you...
Derek: I will remind you who I am, every day. To take care when old, senile, and smelly (writes it down) This is forever. (signs it) Sign.
Meredith: This is our wedding. A post it? (smiles)
Derek: Mhmmm. If you sign it.
Meredith: (signs it, and hands it back. Has tears in her eyes) Now what?
Derek: Now I kiss the bride. (They kiss)
Meredith: (smiling) Married.
Derek: (smiling) Married. (sticks their post it in Mer's locker) You see that? (Mer nods and smiles) Plenty of time.