Amy: I have potential for sexual arousal.
Sheldon: A cross we all must bear.

I obviously have the flu, coupled with sudden on-set Tourette's Syndrome.

I'm prone to night terrors, so if I wake up kicking and screaming, don't panic. Just pin me down and stroke my hair and I'll be fine.

Until you manage to upload your intelligence into a self-sustaining, orbiting satellite equipped with high-speed internet and a cloaking device, you will be dependent on the human race.

Amy: This year's donations may go to, say, the geology department.
Sheldon: Oh dear, not the dirt people.

You don't have to be strong for me. Now let's talk about Priya that man stealing bitch.

Granted, Penny, your secondary sexual characteristics are reasonably bodacious, but Priya is highly educated, she's an accomplished professional, and she comes from the culture that literally wrote the book on neat ways to have sex. Whereas you on the other hand are a community college dropout who comes from the culture that wrote the book on tipping cows.

I'm regretting my earlier cattiness; she's an absolute delight.

Good news! Thanks to you I was able to make a rhesus monkey cry like a disgraced televangelist.

Bernadette: Leonard's really one of a kind.
Amy: Saying that while holding a snowflake is a bit heavy-handed don't you think?

You do understand that it will distract you from the rich variety of sweet loving that your ex-boyfriend is currently receiving from the fiery jewel of Mumbai.

Amy: Sheldon, I am not going through menopause.
Sheldon: Are you sure? You said that with the testy bark of an old bitty.

TBBT Quotes

Oh, Bernadette, please play my clarinet.

Raj's poem

Sheldon: I'll have a diet Coke.
Penny: Can you please order a cocktail? I need to practice mixing drinks.
Sheldon: Fine... I'll have a virgin Cuba Libre.
Penny: That's... rum and Coke without the rum.
Sheldon: Yes, and would you make it diet?