I'm saying, in the spirit of science, what is that little skank's problem?

Sheldon: Amy, mourning the inevitable is a complete waste of time.
Amy: And watching a bunch of goody space movies you've seen hundreds of times isn't?
Sheldon: If we were in a physical relationship, you just lost sex tonight.

Not to mention, your acting career is going south like Sherman. Read about it in your book.

I obviously have the flu, coupled with sudden on-set Tourette's Syndrome.

Amy: This year's donations may go to, say, the geology department.
Sheldon: Oh dear, not the dirt people.

You don't have to be strong for me. Now let's talk about Priya that man stealing bitch.

Until you manage to upload your intelligence into a self-sustaining, orbiting satellite equipped with high-speed internet and a cloaking device, you will be dependent on the human race.

I'm regretting my earlier cattiness; she's an absolute delight.

Good news! Thanks to you I was able to make a rhesus monkey cry like a disgraced televangelist.

Bernadette: Leonard's really one of a kind.
Amy: Saying that while holding a snowflake is a bit heavy-handed don't you think?

Granted, Penny, your secondary sexual characteristics are reasonably bodacious, but Priya is highly educated, she's an accomplished professional, and she comes from the culture that literally wrote the book on neat ways to have sex. Whereas you on the other hand are a community college dropout who comes from the culture that wrote the book on tipping cows.

I'm prone to night terrors, so if I wake up kicking and screaming, don't panic. Just pin me down and stroke my hair and I'll be fine.

TBBT Quotes

Sheldon: Are you still mad about the sperm bank?
Leonard: No!
Sheldon: Do you want to hear an interesting thing about stairs?
Leonard: Not really.
Sheldon: If the height of a single step is off by as little as two millimeters most people will trip.
Leonard: I don't care—two millimeters?! That doesn't seem right.
Sheldon: No, it's true! I did a series of experiments when I was twelve; my father broke his clavicle.

Penny, there's only one cookie with something in the middle that solves life's problems, and that's an Oreo. Or a Nutter Butter, if you're in a pinch.

Sheldon