Yo, P-dog.

Don't be needy, bestie. That's probably part of what chased Leonard away.

Penny, I'm sorry you got dragged into this. I know you're devastated that your ex-boyfriend has an exciting new lover with flawless, camel-colored skin.

Amy: I should let you know that she asked for details about our dalliance.
Sheldon: Interesting. So it went beyond the mere fact of coitus to a "blow by blow" as it were.
Amy: Pun intended?
Sheldon: I'm sorry. What pun?

Amy: The meme has reached full penetration.
Sheldon: Pun intended?
Amy: No. Happy accident.

The real danger is him biting off my face while I'm sleeping.

Amy: Good news: the wildebeest is in the curry.

Commence operation "Priya Wouldn't Wanna Be-ya"

Amy: Although it is ... microbiology.
Sheldon: Your doctorate is in neurobiology. I fail to see the distinction.
Amy: I'll make it simple for you. I study the brain, the organ responsible for Beethoven's Fifth Symphony. Bernadette studies yeast, the organism responsible for Michelob Lite.

Amy: Have you considered massage?
Sheldon: I'd like to respond to that sarcastically: Yes, I relish the thought of a stranger covering my body with oil and rubbing it.
Amy: I was proposing you massage your muscles with your OWN hands.
Sheldon: (aback) Still sounds like a lot of unnecessary touching...

You can't blame yourself. When your prefrontal cortex fails to make you happy promiscuity rewards you with the needed flood of dopamine. We, neurobiologists, refer to this as the skank reflex.

Amy: Sheldon, I am not going through menopause.
Sheldon: Are you sure? You said that with the testy bark of an old bitty.

TBBT Quotes

Oh, Bernadette, please play my clarinet.

Raj's poem

Sheldon: I'll have a diet Coke.
Penny: Can you please order a cocktail? I need to practice mixing drinks.
Sheldon: Fine... I'll have a virgin Cuba Libre.
Penny: That's... rum and Coke without the rum.
Sheldon: Yes, and would you make it diet?