Dean: Who, whoa, whoa, wait? You two know each other?
Crowley: Not in the biblical sense, more of a business relationship I'd say.
Sam: [to Samuel] You're Crowley's bitch.

If the old man's Kermit, whose hand's up his ass?

I've seen some stupid in my time, but you, you take the crown. Putting Jaws in a fish bowl? How do you think it's going to end?

I don't care if you've got soullessness or the freakin mumps. You know better than this!

I don't trust him. Dude's hiding something. I can feel it and if you weren't Robo-Sam, you'd feel it too.

Samuel: This Castiel? You're scrawnier than I pictured.
Castiel: This is a vessel. My true form is approximately the size of your Chrysler Building.
Dean: All right, all right, quit bragging.

Gramps threw a barbeque and left us off the e-vite list?

Dean: I'm sorry. I'm sorry, one more time. Like I'm five. What do you mean he's got no...
Castiel: Somehow when Sam was resurrected, it was without his soul.

Woman: I'm sitting like this so you'll look at my breasts. I just bought them. I need a lot of attention.
Dean: Good luck with that.

Bobby: Did you know my first girl turned out to be a...
Dean: [hangs up] whoa, no.

Dean: You know what I will have that other one [drink].
Bartender: I thought you were working?
Dean: I'm working up to it.

Castiel: It isn't the Horn of Truth.
Dean: What are you talking about? You were gone for like two seconds. Where did you look?
Castiel: Everywhere.

Supernatural Quotes

You betrayed me? No one in the history of torture's been tortured with torture like the torture you'll be tortured with.

Crowley

Castiel: It's very complex. If the pizza man truly loves this babysitter, why does he keep slapping her rear? Perhaps she has done something wrong.
Dean: Are you watching porn? Why?
Castiel: It was there.
Dean: You don't watch porn in a room full of dudes. And you don't talk about it. Just turn it off. Well now he's got a boner.