Howard: Why don't I talk to him about it in May?
Bernadette: In May, you're gonna be on the International Space Station.
Howard: They got a phone.

Howard: You can't do "Buzz." Buzz is taken
Raj: Buzz Lightyear is not real.
Howard: No, that's not what I'm talking about.
Raj: Well, are you talking about when he thought he was real?
Howard: No

Howard: I got pretty exciting NASA news today. Next week I fly to Houston for orientation and zero-gravity elimination drills.
Penny: What does that mean?
Bernadette: He's gonna to learn to poop in space.
Howard: Open the pod bay doors, HAL.
Raj: Maybe your nickname should be "Brown Dynamite."

Bernadette: Who's Siri? Is he dating someone new?
Howard: Yes. His phone.
Bernadette: Is that cute? Or, creepy?

She is gonna break his heart.

[Chuckles] Look at that. There's finally a women in your life you can talk to

Raj: Whoa! What's your hurry, cowboy? Savor the moment.
[Raj and Howard slowly remove the plastic off Raj's new iPhone 4s]
Howard: Oh, yeah.

Bernadette: Boy, I don't know if I could be friends with Howie if we broke up.
Howard: Why not?
Bernadette: I'm a very vengeful person.
Howard: Really?
Bernadette: With access to weaponized smallpox.

Sheldon: Now, where were we? Oh, yes. Does anyone have any wood?
Raj and Howard: [Both snickering]
Sheldon: Oh, come on. I just want wood. Why are you making it so hard?

Sheldon: I want to build a road, but I need wood. Do either of you fellows have wood?
Raj and Howard: [Both chuckling]
Sheldon: I don't understand the laughter. The object of Settlers of Catan is to build roads and settlements. To do so requires wood. Now I have sheep; I need wood. Who has wood for my sheep?

I mean, even Donkey Kong had Donkey Kong, Jr., so he could teach someone how to kidnap princesses and throw barrels at Italian plumbers

Howard: Hey, we're here to support you, buddy.
Leonard: No, you're not. You're here to see if I get my underwear pulled over my head.
Howard: You wore underwear? You fool.

TBBT Quotes

Leonard: Hi. I'm Leonard. You are beautiful. You pop, sparkle and buzz electric. I'm going to pick you up at eight, show you a night you will never forget.
Raj: Where are we going?

Penny, there's only one cookie with something in the middle that solves life's problems, and that's an Oreo. Or a Nutter Butter, if you're in a pinch.

Sheldon