Howard: What do you want us to do about it?
Sheldon: You clearly weren't listening to my topic sentence: Get your women in line!

Howard: Did we just see you pick up a girl in a comic book store?
Stuart: 'Cause if you did, you get your picture up there on the wall on the Wall of Heroes.

Leonard: Oh. Watch out, Sheldon. This little boy Casper is a g-g-g-ghost!
Sheldon: Droll.
Howard: Not as droll as a grown man passed out in a puddle of his own urine.
Leonard: That was pretty droll. With a hint of ammonia.

Raj: None of our gods have abs like that.
Howard: Yep, that's the last Jew who did sit-ups. And look where it got him.

Sheldon's mom: I bet your mom is really proud of you.
Howard: Nope. She says if I don't back out, she's gonna go on a hunger strike. It'd take years before she'd be in any kind of danger, but still....

Howard: You know, there's a saying we have at NASA. What makes the right stuff so right is that it always comes home.
Bernadette: Stop talking, Howard.

Bernadette: Are those Russian rockets safe?
Howard: Well, I mean, safe as it can be when it was build by the good folks who brought you Chernobyl.

Raj: Whatever, dude. She kissed me.
Howard: It might've been on your lips but it was my kiss.
Raj: Oh, fine, let's agree she kissed both of us.
Howard: Okay.

Raj: Okay, I'm going to play it cool. Tell her, "Maybe. Whatever, babe."
Howard [translating in sign language to Emily]: He'll text you.

Leonard: See, this is the good thing about having a girlfriend 9,000 miles away I can spend my nights doing whatever I want.
Howard: You mean playing nerd games with us and then taking a suspiciously long shower?
Leonard: Maybe.

Howard: Can you believe grown men sit around and play with toy trains?
Bernadette: That's pretty big talk for a man with a closet full of magic tricks at his mother's house.

Howard: This may be hard for you to hear, but when I say "honey," I mean my fiancee.
Raj [whispers into Howard's ear]
Howard: Yeah, well, now it means her.

TBBT Quotes

Penny, there's only one cookie with something in the middle that solves life's problems, and that's an Oreo. Or a Nutter Butter, if you're in a pinch.

Sheldon

Penny: Here's a question-- as an alien pretending to be human, are you planning to engage in any post-prom mating rituals with Amy?
Sheldon: There are post-prom mating rituals?
Penny: Not always. Unless your date drives a van with an air mattress, then always.
Sheldon: Well, if it's part of the prom experience, then I'm open to it.
Penny: You're kidding.
Sheldon: I may be an alien, but I have urges.If Amy wants to copulate by firing her eggs into space, well, then, I will happily catch them with the reproductive sac on my upper flermin. I'm not the best at reading facial cues, but I can see that you're a little turned on.